Pulmonary Parenchymal Lesions Clinical Trial
Official title:
Comparing the Diagnostic Yield of Radial Endo-Bronchial Ultra-Sound Guided Biopsy When Using a Thick (1.7mm) With an Aspiration Needle Biopsy Vs. a Thin USS Probe (1.4mm), in Peripheral Lung Lesions.
Obtaining a tissue sample to diagnose parenchymal lung lesions (PPL) suspected of cancerous
origin is of utmost importance. Due to it's markedly favourable safety profile, a
bronchoscopic biopsy method called Radial EBUS is becoming increasingly popular. However, a
meta-analysis reports the success rate of Radial EBUS in diagnosis is 73%, which in
comparison to CT guided biopsy which is the gold standard in diagnosing PPL (90% success
rate), is sub-optimal.
There are 2 types of USS probes used in the R-EBUS procedure. Whilst the thicker USS probe
(1.7mm) is capable of accommodating larger biopsy instruments, the thinner USS probe could
be advanced more peripherally to obtain a biopsy.
Therefore identifying what type of USS probe is better for a given PPL will aid in improving
the diagnostic yield.
In this study, investigators compare these two types of probes in the ability to diagnose a
PPL.
The biopsy instruments used for both arms are forceps and cytology brush. For the thick USS
arm, in addition, an aspiration needle will also be used. (The thin USS guide sheath is too
small to accommodate an aspiration needle)
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic