Clinical Trials Logo

Clinical Trial Summary

Patients found pulmonary nodules by CT screening by will be enrolled in this study prospectively. Plasma cfDNA sequencing of these patients will be used to diagnose and monitor benign and malignant pulmonary nodules.


Clinical Trial Description

This study prospectively included patients with pulmonary nodules (0.5-3 cm) diagnosed by CT. Methylation of plasma cfDNA in these patients will be performed. Evaluation of benign and malignant diagnostic efficacy of cfDNA methylation in pulmonary nodules with definite pathological findings. Pulmonary nodules that temporarily not require invasive examination will be performed CT follow-up and dynamically monitored methylation changes of cfDNA. And the methylation changes were to establish a model for the diagnosis and monitor of benign and malignant pulmonary nodules. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03989219
Study type Observational
Source Shanghai Chest Hospital
Contact
Status Completed
Phase
Start date August 15, 2018
Completion date June 30, 2022

See also
  Status Clinical Trial Phase
Completed NCT03649906 - A Clinical Study of Optimized CT-guided Pulmonary Nodule Microcoil Localization Technique N/A
Completed NCT05963945 - Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
Completed NCT04066699 - Percutaneous Localization: Open-label Registry of Thoracic Surgery
Not yet recruiting NCT05477251 - Comparative Study on the Efficacy and Safety of Microwave Ablation and Lobectomy in the Treatment of Ground Glass Nodules Located in the Pulmonary Hilar Region N/A
Completed NCT03591445 - Is Bronchoscopy Necessary in the Preoperative Workup of GGO Lung Cancer?(ECTOP-1005) N/A
Withdrawn NCT04894682 - Safety and Long-term Effects of COVID-19 Vaccines in Patients With Pulmonary Tumor
Recruiting NCT03790735 - The MDA Test to Differentiate of Benign and Malignant Pulmonary Nodules
Active, not recruiting NCT03992183 - Utility of CAML as Diagnostic for Early Stage Lung Cancer
Recruiting NCT04552054 - Mixed Reality Technique Combined With 3D Printing Navigational Template for Localizing Pulmonary Nodules N/A
Recruiting NCT05389774 - DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
Recruiting NCT06308120 - A Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB N/A
Completed NCT04209972 - The Benefit of UHR-CT: Precision of Repeated Volume Measurements of Pulmonary Nodules N/A
Completed NCT03181490 - Circulating Tumor DNA Methylation Test to Differentiate Benign and Malignant Pulmonary Nodules
Recruiting NCT05445635 - Added Value of a Small Camera (Iriscope) in the Endoscopic Diagnosis of Peripheral Lung Nodules and Masses N/A
Recruiting NCT04270799 - Lung Nodule Imaging Biobank for Radiomics and AI Research
Recruiting NCT00841750 - Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection Phase 3
Recruiting NCT06426628 - Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
Recruiting NCT05415670 - Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Recruiting NCT04005677 - The Early Diagnosis of Pulmonary Nodule Based on Multi-dimension Messages
Recruiting NCT05968898 - Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES N/A