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Methylation of cfDNA in Diagnosing and Monitoring Pulmonary Nodule

Pulmonary Nodule, Solitary Clinical Trial

Official title:
Methylation of cfDNA in Diagnosing and Monitoring Benign and Malignant Pulmonary Nodule

Clinical Trial Summary

Patients found pulmonary nodules by CT screening by will be enrolled in this study prospectively. Plasma cfDNA sequencing of these patients will be used to diagnose and monitor benign and malignant pulmonary nodules.

Clinical Trial Description

This study prospectively included patients with pulmonary nodules (0.5-3 cm) diagnosed by CT. Methylation of plasma cfDNA in these patients will be performed. Evaluation of benign and malignant diagnostic efficacy of cfDNA methylation in pulmonary nodules with definite pathological findings. Pulmonary nodules that temporarily not require invasive examination will be performed CT follow-up and dynamically monitored methylation changes of cfDNA. And the methylation changes were to establish a model for the diagnosis and monitor of benign and malignant pulmonary nodules. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03989219
Study type Observational
Source Shanghai Chest Hospital
Contact
Status Completed
Phase
Start date August 15, 2018
Completion date June 30, 2022
View Details
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