Data Acquisition Study With Artificial Intelligence and Phenotyping of Patients With Acute Pulmonary Embolism

Pulmonary Embolism Clinical Trial

— PEPITE  

Official title:

Data Acquisition Study With Artificial Intelligence and Phenotyping of Patients Who Presented With Acute Pulmonary Embolism

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06183944
• Other study ID #: 2023-CHITS-016
• Status: Recruiting
• Start date: December 11, 2023
• Est. completion date: July 1, 2026

Study information

• Verified date: March 2024
• Source: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
• Contact: Jean-Philippe Suppini
• Phone: 04 94 14 55 25
• Email: recherche.promotion[@]ch-toulon.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The initial aim is to build and validate artificial intelligence tools (machine learning and Natural Language Processing) to acquire and structure data from medical reports at the Centre Hospitalier Intercommunal de Toulon - la Seyne sur mer (CHITS). This project will build upon work previously done by the Department of Epidemiology, Biostatistics and Health Data (DEBDS) at the Centre Antoine Lacassagne (CAL) in Nice, focusing on breast and thyroid cancers. The idea is to validate the transferability of these tools to another establishment with different pathologies and practitioners, specifically the vascular medicine department at CHITS.

Subsequently, the aim will be to identify clinically relevant phenotypes in patients with acute pulmonary embolism. Hierarchical clustering methods combined with unsupervised learning (machine learning) will be used to obtain groups of patients who are homogeneous at diagnosis. Evaluating their prognosis at 6 months (recurrence or chronic thromboembolic pulmonary hypertension), account the first 3 months of anticoagulant treatment, would provide an aid to medical decision-making.

This research will include a retrospective and a prospective parts. The retrospective part will include patients who have been admitted to CHITS for acute pulmonary embolism since 2019. For the prospective part, it is planned to include patients with same characteristics over the years 2024 and 2025. More than 2,500 patients are expected to be included.

This research will have no impact on current patient care. Data from consultations and various examinations carried out as part of care will be collected for six months post-diagnosis in order to meet the research objectives.

Description:

Context :

Artificial Intelligence : NLP, clustering and unsupervised learning:

Artificial Intelligence (AI) is a field that combines computer science with data sets, with the aim of enabling a machine to imitate the cognitive abilities of human being. Machine learning (ML) and its sub-domain deep learning, which uses layers of neurons, are two major sub-domains of AI. The difference lies in training of each algorithm. Two distingued methods are used by ML : supervised learning, which involves training a model on known input and output data to predict future outputs, and unsupervised learning involves the discovery of hidden patterns and intrinsic underlying structures in the input data. Natural Language Processing (NLP) is also a subfield of AI, but it generally requires ML to be effective. NLP processes real-world linguistic data to make sense of it in a way that a computer can understand.

NLP has two main stages: data pre-processing and algorithm development. Programming languages such as Python or R are widely used for these techniques.

The aim of clustering methods is to group a set of individuals into homogeneous classes. Non-hierarchical methods can be used to classify massive data but require to fixe in advance the number of classes. Hierarchical methods, which are more time-consuming to compute, consist of a series of nested partitions represented by a clustering tree. The optimal number of classes can be determined a posteriori by reading the tree. In presence of a large number of individuals, it is common to combine non-hierarchical and hierarchical techniques. When classes are not clearly known in advance, clustering methods are use with unsupervised learning (ML) [1]. Datasets are generally divided into three disjoint datasets: training data, used to train the chosen algorithm(s); validation data, used to check performance of result; and test data, used only at the end of the process.

Venous thromboembolic disease:

Venous thromboembolic disease (VTE) is a common pathology whose incidence is imperfectly known, but increases with age, reaching 1% in subjects over 75 years old. In France, it is estimated that every year over 100,000 people develop VTE, which is responsible for between 5,000 and 10,000 deaths. Deep vein thrombosis (DVT) and pulmonary embolism (PE) are the two main types of VTE. DVT corresponds to partial or total occlusion of a deep vein by a thrombus, most often localized in the lower limbs. PE is defined as partial or total occlusion of the pulmonary arteries or their branches. The main risk of DVT is the occurrence of PE, which can be life threatening. Other VTE-specific complications and possible adverse outcomes include thromboembolic recurrence (either DVT or PE), chronic thromboembolic pulmonary hypertension and post-thrombotic syndrome in DVT. Current management of VTE is mainly based on anticoagulant therapy. The duration of treatment varies according to the estimated risk of recurrence if treatment is withdrawn, essentially depending on whether or not there is a prior major risk factor [2]. In this subgroup of PE patients, in the absence of major risk factors, risk of recurrence is considered intermediate and varies according to whether the event is a first episode or a recurrence, and whether there are obstructive pulmonary sequelae or not [3]. More recently, the therapeutic strategy has become more complex, with inclusion of minor risk factors that modulate duration of treatment without relevant evidence. Moreover, regardless of the duration of treatment, the dosage of anticoagulation beyond the sixth month is uncertain for Direct Oral Anticoagulants.

Hypotheses :

This research is presented under two distinct axis :

AXIS 1: The aim of this work will initially be to develop and validate artificial intelligence tools, using ML and NLP, for acquiring and structuring data from text-based medical reports in department of vascular medicine at the Centre Hospitalier Intercommunal de Toulon - la Seyne sur mer (CHITS). This project will build upon work previously done by the Department of Epidemiology, Biostatistics and Health Data (DEBDS) at the Centre Antoine Lacassagne (CAL) focusing on breast and thyroid cancers [5,6,7]. The idea is to validate transferability of these tools to another establishment with different pathologies and practitioners, specifically the vascular medicine department of CHITS.

Implementing a method of acquiring structured data using artificial intelligence techniques directly from textual medical reports within our hospital is a challenge. If its performance is proven and this tool is implemented on a permanent routinely basis, it would provide an easily exploitable source of information. The diversity of fields and interests in clinical research in our establishment may make deployment in other departments an achievable goal. For CHITS, this is the first step in the process of building a Health Data Warehouse (HDW).

AXIS 2: Subsequently, the aim will be to use the database to identify clinically relevant phenotypes in patients with acute pulmonary embolism. Hierarchical clustering methods combined with unsupervised learning (machine learning) will be used to obtain groups of patients who are homogeneous at diagnosis. Evaluating their prognosis at 6 months (recurrence or chronic thromboembolic pulmonary hypertension), account the first 3 months of anticoagulant treatment, would provide an aid to medical decision-making.

An analysis of the six-month evolution of homogeneous patient groups with acute pulmonary embolism, constructed using clustering methods with unsupervised learning has never been conducted before. This innovative project within a large-scale hospital infrastructure is likely to offer doctors a decision-making aid, and patients a scientifically-validated form of therapeutic management.

Material and Methods :

This research will include a retrospective and a prospective parts. The retrospective part will include patients who have been admitted to CHITS for acute pulmonary embolism since 2019 (around 1900 patients). For the prospective part, it is planned to include patients with same characteristics over the years 2024 and 2025 (approximately 765 patients). If individual information is not available or they object to the processing of their data for 25% of the patients, a large volume of data on over 2,500 patients could potentially be analysed in this trial. This research will have no impact on current patient care. Data from consultations and various examinations carried out as part of the care will be collected for six months post-diagnosis to meet the research objectives.

AXIS 1: The data acquisition method used in this research will be twofold. Data from patients included in clinical research will be collected conventionally using a case report form, then centralized and organized in a reference database called "Gold Standard", and entered by a clinical research technician. The second technique of data acquisition, using NLP methods, will proceed in several stages, in parallel with previous approach. First, the extraction of medical reports (MR) in text format will be followed by a pseudonymization stage. The MR dataset will then be prepared for training and validation by removing special characters and identifying segment of interests. Then, MR will be annotated with BRAT in order to identify the terms that will be used to populate the database. Training scripts will be applied on 70% of patients in order to create NLP models. During this training phase, post-processing medical rules will be written in order to translate the information identified by the models into structured data. The script thus finalized is applied to the validation base with an evaluation of its performance. After any necessary adjustments, the performance of final script is evaluated on the test database. Performance will be assessed by comparing data obtained automatically with the manual Gold Standard database.

AXIS 2 : Unsupervised clustering methods used in this study combine hierarchical and non-hierarchical methods. Following the hierarchical ascending clustering, Ward's index is used to determine the number of groups of interest. The centroids of these groups are then considered to initialize a partitioning algorithm, such as the k-means algorithm. Once most medically relevant groups have been determined, six-month evolution (stable, aggravation or progress) are compared. Factors influencing progression during the first three months of treatment can also be included in a statistic model, depending on their ability to predict aggravation. All these explorations should provide a basis for medical decision-making.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2500
• Est. completion date: July 1, 2026
• Est. primary completion date: July 1, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age = 18 years;

• Patient with acute pulmonary embolism in CHITS (hospitalised or not).

Exclusion Criteria:

• Sub-segmental pulmonary embolisms ;

• Patient opposition.

Related Conditions & MeSH terms

• Embolism
• Pulmonary Embolism

Intervention

Other:
• Hierarchical clustering methods
Hierarchical clustering methods will be used to form homogeneous groups of patients based on their data at diagnosis: presence or absence of symptoms, clinical and biological data, and presence or absence of favouring factors. Patient evolution at 6 months can fall into categories: stable, aggravation or progress, which are determined by events such as recurrence, hemorrhage, functional sequelae or death.

Locations

Country	Name	City	State
France	centre hospitalier intercommunal Toulon La Seyne sur Mer - Internal and vascular medicine	Toulon

Sponsors (2)

Lead Sponsor	Collaborator
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer	Centre Antoine Lacassagne

Country where clinical trial is conducted

France, 

References & Publications (5)

Duffett L, Castellucci LA, Forgie MA. Pulmonary embolism: update on management and controversies. BMJ. 2020 Aug 5;370:m2177. doi: 10.1136/bmj.m2177. — View Citation

Gal J, Bailleux C, Chardin D, Pourcher T, Gilhodes J, Jing L, Guigonis JM, Ferrero JM, Milano G, Mograbi B, Brest P, Chateau Y, Humbert O, Chamorey E. Comparison of unsupervised machine-learning methods to identify metabolomic signatures in patients with localized breast cancer. Comput Struct Biotechnol J. 2020 Jun 3;18:1509-1524. doi: 10.1016/j.csbj.2020.05.021. eCollection 2020. — View Citation

Gallo A, Valerio L, Barco S. The 2019 European guidelines on pulmonary embolism illustrated with the aid of an exemplary case report. Eur Heart J Case Rep. 2021 Jan 4;5(2):ytaa542. doi: 10.1093/ehjcr/ytaa542. eCollection 2021 Feb. — View Citation

Schiappa R, Contu S, Culie D, Chateau Y, Gal J, Pace-Loscos T, Bailleux C, Haudebourg J, Ferrero JM, Barranger E, Chamorey E. Validation of RUBY for Breast Cancer Knowledge Extraction From a Large French Electronic Medical Record System. JCO Clin Cancer Inform. 2023 May;7:e2200130. doi: 10.1200/CCI.22.00130. — View Citation

Yu T, Shen R, You G, Lv L, Kang S, Wang X, Xu J, Zhu D, Xia Z, Zheng J, Huang K. Machine learning-based prediction of the post-thrombotic syndrome: Model development and validation study. Front Cardiovasc Med. 2022 Sep 16;9:990788. doi: 10.3389/fcvm.2022.990788. eCollection 2022. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	AXIS 1 - Primary : Develop a robust tool for acquiring structured data directly from text-based medical reports	The tool will be implemented using NLP methods, mainly developed in PYTHON. The performance of the implemented tool will be evaluated by comparing data generated by this tool with data entered manually ('Gold Standard' database).	30 months
Primary	AXIS 2 - Primary: Identify homogeneous groups of patients based on their medical characteristics at diagnosis, and then compare their evolution at 6 months.	Hierarchical clustering methods will be used to form homogeneous groups of patients based on their data at diagnosis: presence or absence of symptoms, clinical and biological data, and presence or absence of favouring factors. Patient evolution at 6 months can fall into categories: stable, aggravation or progress, which are determined by events such as recurrence, hemorrhage, functional sequelae or death.	6 months
Secondary	AXIS 2 - Secondary: Determine factors predictive of 6-month progression within the first three months of treatment.	A priori, groups defined for primary objective will be maintained. Factors considered during the first three months of treatment will include: clinical and biological data, presence or absence of symptoms, favorable factors or complications.	3 months