Assessment of Right Ventricular Function After Acute Pulmonary Embolism Using Speckle Tracking Echocardiography

Pulmonary Embolism Clinical Trial

Official title:

Assessment of Right Ventricular Function After Acute Pulmonary Embolism Using Speckle Tracking Echocardiography

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04609605
• Other study ID #: speckle tracking in PE
• Status: Not yet recruiting
• Phase: N/A
• Start date: December 2020
• Est. completion date: January 2022

Study information

• Verified date: November 2020
• Source: Assiut University
• Contact: Mahmoud Said rashwan, master degree of cardiology
• Phone: 01007949203
• Email: dr.ma7moudsaid[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

1. To asses regional RV function in patients presented with acute pulmonary embolism using speckle tracking echocardiography

2. To evaluate its relationship to long term mortality.

Description:

Pulmonary embolism (PE) is the third most common cardiovascular cause of death after myocardial infarction and stroke . The incidence of PE has been increasing ,with significant associated mortality; a recent registry of PE patients reported a mortality rate > 10% at 30 days. There are a number of emerging contemporary PE therapies, including thrombolysis, catheter intervention and surgery. Early and accurate identification of PE in patients is therefore critical. A transthoracic echocardiogram (TTE) may help when there is a clinical suspicion for PE, and its use in confirmed PE is widely recommended . A number of right atrial (RA) and right ventricular (RV) parameters have been shown to be abnormal in patients with PE . In addition, RA and RV enlargement portends a worse prognosis in these patients .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 68
• Est. completion date: January 2022
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

1. clinical diagnosis of acute pulmonary embolism

2. Age: 20 - 70 years.

Exclusion Criteria:

1. coronary artery disease

2. patient of Atrial fibrillation.

3. Patient of impaired RV function due to chest disease (Cor-pulmonale)

4. patient with impaired Ejection fraction (EF) <50%

5. Moderate to severe valvular heart disease.

6. Atrio-ventricular conduction disturbance.

7. Poor echogenicity

Related Conditions & MeSH terms

• Embolism
• Pulmonary Embolism

Intervention

Device:
• speckle tracking echocardiography
speckle tracking echocardiography of right ventricle

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (4)

Fields JM, Davis J, Girson L, Au A, Potts J, Morgan CJ, Vetter I, Riesenberg LA. Transthoracic Echocardiography for Diagnosing Pulmonary Embolism: A Systematic Review and Meta-Analysis. J Am Soc Echocardiogr. 2017 Jul;30(7):714-723.e4. doi: 10.1016/j.echo.2017.03.004. Epub 2017 May 9. Review. — View Citation

McConnell MV, Solomon SD, Rayan ME, Come PC, Goldhaber SZ, Lee RT. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol. 1996 Aug 15;78(4):469-73. — View Citation

Trivedi SJ, Altman M, Stanton T, Thomas L. Echocardiographic Strain in Clinical Practice. Heart Lung Circ. 2019 Sep;28(9):1320-1330. doi: 10.1016/j.hlc.2019.03.012. Epub 2019 Apr 12. Review. — View Citation

Wendelboe AM, Raskob GE. Global Burden of Thrombosis: Epidemiologic Aspects. Circ Res. 2016 Apr 29;118(9):1340-7. doi: 10.1161/CIRCRESAHA.115.306841. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	improve management of acute pulmonary embolism	comparison between speckle tracking echocardiograpgy and conventional echocardiography in pulmonary embolism	baseline