Pulmonary Rehabilitation to Improve Physical Capacity After Pulmonary

Status Active, not recruiting

Clinical Trial Summary

This project aims to evaluate a rehabilitation program as treatment and uncover potential pathophysiological mechanisms of a newly identified chronic condition named "Post Pulmonary Embolism Syndrome" (PPS).

Clinical Trial Description

The newly identified Post Pulmonary Embolism Syndrome (PPS) is characterized by chronic persistent, but unexplained dyspnea (i.e. without signs of pulmonary hypertension or pulmonary abnormality). Symptoms are considerable, but less severe than in CTEPH patients. A recent study performed by our group confirmed that up to 50% of our patients complained of various grades of persistent unexplained dyspnea 1-10 years after the diagnosis of PE. In this multifaceted project we wish to evaluate the effect of an eight week rehabilitation program led and supervised by a trained physiotherapist on exercise capacity in PPS patients. This interventional part of the study will be formed as a randomized controlled trial. Patients will be randomized to either usual care or a physiotherapist-supervised rehabilitation program. The study also aims to explore potential underlying pathophysiological mechanisms in PPS, using state of the art methods such as cardiac magnetic resonance imaging and transthoracic echocardiography involving novel methods focusing on the right ventricle. The pathophysiological part of the study will be formed as a case control study, where post PE-patients who do not fulfill the criteria for PPS will serve as controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03405480
Study type	Interventional
Source	Ostfold Hospital Trust
Contact
Status	Active, not recruiting
Phase	N/A
Start date	January 20, 2018
Completion date	March 30, 2024

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Pulmonary Rehabilitation to Improve Physical Capacity After Pulmonary Embolism

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms