NAC, NaHCO3 and NS Prophylaxis for CTPA in the ED on Suspicion of PE: A Randomized Controlled Trial

Pulmonary Embolism Clinical Trial

Official title:

N-acetylcysteine, Sodium Bicarbonate and Normal Saline Alone Prophylaxis for Spiral Computed Tomography Pulmonary Angiography in the Emergency Department on Suspicion of Pulmonary Emboli: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02483143
• Other study ID #: 2014/47
• Status: Completed
• Phase: Phase 4
• First received: May 27, 2015
• Last updated: June 23, 2015
• Start date: February 2014
• Est. completion date: February 2015

Study information

• Verified date: June 2015
• Source: Karadeniz Technical University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Study objective:

The purpose of this study was to compare the role of the prophylactic protocols N-acetylcysteine (NAC) plus normal saline, sodium bicarbonate (NaHCO3) plus normal saline and intravenous normal saline (NS) alone in the prevention of contrast-induced nephropathy (CIN) after computed tomography pulmonary angiography (CTPA) in emergency patients with suspected pulmonary embolism (PE).

Materials and methods:

This study was planned as randomized, double blind, placebo controlled clinical research. Patients presenting to the emergency department within a 1-year period, undergoing CTPA on suspicion of PE and having one or more risk factors for development of CIN were included in the study. The NAC group received 1 ml/3 mgr NAC+NS solution 1 h before CTPA and 1 ml/kg per hour for a minimum 6 h after CTPA. The NaHCO3 group received 132 mEq NaHCO3+NS solution for 1 h before CTPA and 1 ml/kg per hour for a minimum of 6h after CTPA. The normal saline (NS) group received 3 ml/kg NS for 1 h before CTPA and 1 ml/kg per hour NS for a minimum 6 h after CTPA. CIN was evaluated as the primary outcome, and moderate renal injury (defined as a 100% increase in serum creatinine levels), severe renal insufficiency requiring hemodialysis or peritoneal dialysis) or in-hospital mortality as secondary outcomes.

Description:

Study Design and Setting This randomized, double blind, placebo control study was performed in the emergency department of a tertiary care university hospital in Turkey receiving >100,000 patient presentations annually. Approval was granted by the Karadeniz Technical University institutional ethical committee. Written and informed consent was received from all patients enrolled. The data collected period commenced on 1 February 2014, and the study period lasted for 1 year until 1 February 2015.

Selection of Participants Patients undergoing contrast enhanced thoracic tomography due to suspected PE, aged over 18, with measureable basal creatinine levels pre-tomography and measurable serum creatinine levels 48-72 h post-tomography and with one or more of the risk factors for CIN cited below were enrolled. The risk factors were pre-existing renal dysfunction (Cre 1.4 mg/dl or a high or calculated glomerular filtration rate <60 ml/min/1.73 m2), diabetes mellitus, hypertension receiving treatment, hypotension (SBP<90 mmHg), coronary artery disease, history of nephrotoxic drug use (NSAID, cisplatin, aminoglycoside, amphotericin B), liver disease, congestive heart failure (active or history thereof), age 65 or over, and anemia (Htc <30%). Patients refusing to participate or to provide informed consent, end stage renal patients already in peritoneal dialysis or hemodialysis, pregnant women, subjects with a known allergy to N-acetylcysteine or Na-bicarbonate, patients requiring NAC therapy or Na-bicarbonate therapy for existing additional disease, and patients exposed to contrast material for any reason in the previous 2 days were excluded. In addition, if the study protocol was considered by the physician responsible for treatment in the emergency department as being liable to delay medical care or have adverse effects, or if any of the drugs in the protocol were thought to be contraindicated, such patients were also excluded.

Interventions Computer-based block randomization was employed to randomize subjects. Three groups, A, B and C were established, each representing a drug branch treatment code.

The diagnostic approach algorithm to be applied in patients with suspected PE and the planning of treatment of PE were based on the 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism.

In the NAC group; 3 gr NAC was made up to 1000 ml with NS; a 1 ml/3 mgr NAC solution was obtained and 3 ml/kg NAC+NS solution was administered for 1 h before CTPA and a 1 ml/kg per hour NAC+NS solution was administered for a minimum 6 h after CTPA. In the NaHCO3 group; 132 mEq NaHCO3 was made up to 1000 ml with NS; and 3 ml/kg NaHCO3+NS solution was administered for 1 h before CTPA and 1 ml/kg per hour NaHCO3+NS solution was administered for a minimum of 6 h after CTPA. In the NS group: 3 ml/kg NS was administered for 1 h before CTPA and 1 ml/kg per hour was administered for a minimum of 6 h after CTPA.

Clinical follow-up Post-CTPA prophylactic infusion was maintained for at least 6 h. Patients unable to complete that period were removed from the study and not included in the analysis.

Patients were regularly observed by the physician responsible for patient monitoring and by authors blind to the prophylactic alternatives received throughout the study. Creatinine measurements required for determining CIN development in 48 to 72 h were performed in the departments in which patients were hospitalized, while discharged patients were invited to return to the emergency department where venous blood specimens were collected using phlebotomy.

Outcome Measures CIN development (an increase ≥25% or 0.5 mg/dl in creatinine levels 48-72 h after contrast exposure compared to basal levels) was evaluated as the primary outcome in the study.

A secondary outcome was assessed as moderate renal injury developing during hospitalization (defined as a 100% increase in serum creatinine levels, severe renal failure requiring hemodialysis or peritoneal dialysis) or in-hospital mortality. Patients were monitored throughout hospitalization until either discharge or mortality.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 231
• Est. completion date: February 2015
• Est. primary completion date: February 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

1. Patients undergoing contrast enhanced thoracic tomography due to suspected PE

2. aged over 18 years old

3. Measureable basal creatinine levels pre-tomography and measurable serum creatinine levels 48-72 h post-tomography

4. with one or more of the risk factors for CIN cited below were enrolled.

The risk factors were pre-existing renal dysfunction (Cre 1.4 mg/dl or a high or calculated glomerular filtration rate <60 ml/min/1.73 m2), diabetes mellitus, hypertension receiving treatment, hypotension (SBP<90 mmHg), coronary artery disease, history of nephrotoxic drug use (NSAID, cisplatin, aminoglycoside, amphotericin B), liver disease, congestive heart failure (active or history thereof), age 65 or over, and anemia (Htc <30%).

Exclusion criteria:

1. Patients refusing to participate or to provide informed consent

2. End stage renal patients already in peritoneal dialysis or hemodialysis

3. Pregnant women

4. Subjects with a known allergy to N-acetylcysteine or Na-bicarbonate

5. Patients requiring NAC therapy or Na-bicarbonate therapy for existing additional disease

6. Patients exposed to contrast material for any reason in the previous 2 days were excluded.

7. If the study protocol was considered by the physician responsible for treatment in the emergency department as being liable to delay medical care or have adverse effects, or if any of the drugs in the protocol were thought to be contraindicated, such patients were also excluded.

8. Patients unable to receive post-CT infusion for a minimum of 6 h were also excluded.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Embolism
• Pulmonary Embolism
• Radiographic Contrast Agent Nephropathy

Intervention

Drug:
• NAC
3 gr NAC was made up to 1000 ml with NS; a 1 ml/3 mgr NAC solution was obtained and 3 ml/kg NAC+NS solution was administered for 1 h before CTPA and a 1 ml/kg per hour NAC+NS solution was administered for a minimum 6 h after CTPA.
• NaHCO3
132 mEq NaHCO3 was made up to 1000 ml with NS; and 3 ml/kg NaHCO3+NS solution was administered for 1 h before CTPA and 1 ml/kg per hour NaHCO3+NS solution was administered for a minimum of 6 h after CTPA.
• Normal Saline
3 ml/kg NS was administered for 1 h before CTPA and 1 ml/kg per hour was administered for a minimum of 6 h after CTPA.

Locations

Country	Name	City	State
Turkey	Karadeniz Technical University Faculty of Medicine	Trabzon

Sponsors (1)

Lead Sponsor	Collaborator
Karadeniz Technical University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Contrast induced nephropathy (CIN) development	An increase =25% or 0.5 mg/dl in creatinine levels 48-72 h after contrast exposure compared to basal levels	Post contrast 48-72 hour	Yes
Secondary	moderate renal injury developing	Number of participants who have 100% increase in serum creatinine levels	up to 4 weeks, participants were followed for the duration of hospital stay, an expected average of 4 weeks	Yes
Secondary	severe renal failure developing	Number of participants who require hemodialysis or peritoneal dialysis for the duration of hospital stay	up to 4 weeks, participants will be followed for the duration of hospital stay, an expected average of 4 weeks	Yes
Secondary	in-hospital mortality	Number of participants who die in the duration of hospital stay hospital. Patients were monitored throughout hospitalization until either discharge or mortality.	up to 4 weeks, participants will be followed for the duration of hospital stay, an expected average of 4 weeks	Yes