Puberty, Precocious Clinical Trial
Official title:
Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty
NCT number | NCT04012632 |
Other study ID # | szCDC_1 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | September 1, 2016 |
Est. completion date | July 4, 2019 |
Verified date | July 2019 |
Source | Shenzhen Center for Disease Control and Prevention |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.
Status | Completed |
Enrollment | 628 |
Est. completion date | July 4, 2019 |
Est. primary completion date | May 20, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 7 Years to 10 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of central precocious puberty or early and fast puberty. Exclusion Criteria: - The participants who were not the first visit to the hospital and had been treated before. - The participants who were with endocrine disorders. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Shenzhen Center for Disease Control and Prevention |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the polymorphism in the KISS1/GPR54 pathway genes | functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected. | 3 months |
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