Psoriatic Nails Clinical Trial
Official title:
Comparison of Efficacy and Safety of Psoriatic Nails Treatment Between by Intralesional 0.1%Triamcinolone Injection and Topical 0.05%Clobetasol Propionate Ointment
Psoriatic nails can significantly affect a quality of life of patients. Psoriasis affects
both nail matrix and nail bed. Pitting, leukonychia and red spots in lunula indicate a
defect in the nail matrix. Psoriasis can change the nail bed as the results in onycholysis,
discoloration, splinter hemorrhage and subungual hyperkeratosis. The main treatment of
psoriatic nails is using topical high- potent steroids however topical steroids are limited
their ability to penetrate deep nail matrix or nail bed which are the main pathology. Use of
such a treatment can lead to skin atrophy and report in the case of "Disappearing digits".
Previous studies of steroid injection in the treatment of psoriatic nails show satisfactory
results without any serious permanent adverse effects. At present, there is no comparison
study between intralesional steroid and ultrapotent topical steroid for the treatment of
psoriatic nails.
The purpose of the study is to evaluate the efficacy and safety of intralesional
triamcinolone comparing to 0.05% clobetasol ointment in the treatment of psoriatic nails.
Psoriasis is a chronic inflammatory disorder. The nails involvement has been reported up to
40% of psoriatic patients. Psoriatic nails can significantly affect a quality of life of
patients. Psoriasis affects both nail matrix and nail bed. Pitting, leukonychia and red
spots in lunula indicate a defect in the nail matrix. Psoriasis can change the nail bed as
the results in onycholysis, discoloration, splinter hemorrhage and subungual hyperkeratosis.
The main treatment of psoriatic nails is using topical high- potent steroids however topical
steroids are limited their ability to penetrate deep nail matrix or nail bed which are the
main pathology. Use of such a treatment can lead to skin atrophy and report in the case of
"Disappearing digits". Previous studies of steroid injection in the treatment of psoriatic
nails show satisfactory results without any serious permanent adverse effects. At present,
there is no comparison study between intralesional steroid and ultrapotent topical steroid
for the treatment of psoriatic nails.
The purpose of the study is to evaluate the efficacy and safety of intralesional
triamcinolone comparing to 0.05% clobetasol ointment in the treatment of psoriatic nails.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment