A Study of DS-1211b in Individuals With PseudoXanthoma Elasticum

Status Completed

Clinical Trial Summary

This study was designed to evaluate the safety, tolerability, pharmacodynamics (PD) of DS-1211b, and pharmacokinetics (PK) in individuals with Pseudoxanthoma elasticum (PXE). PXE is a rare disease that is associated with significant risks of visual impairments and comorbidity from peripheral and cardiovascular diseases, and adversely impacts the quality of life in afflicted individuals.

Clinical Trial Description

DS-1211b, a potent small-molecule inhibitor of tissue-nonspecific alkaline phosphatase, is being developed for the treatment ectopic calcification diseases such as PXE. This study will assess DS-1211b (low-, middle-, and high-dose tablets) administered once daily for 12 weeks in individuals with PXE. ;

Study Design

Related Conditions & MeSH terms

Pseudoxanthoma Elasticum

Clinical Trial Details

NCT number	NCT05569252
Study type	Interventional
Source	Daiichi Sankyo
Contact
Status	Completed
Phase	Phase 2
Start date	October 20, 2022
Completion date	November 15, 2023

View Details

See also
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