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NCT05634083 Clinical Trial

Does Indoxyl Sulfate Have a Role in Uremic Pruritus?

Pruritus Clinical Trial

Official title:
Does Indoxyl Sulfate Have a Role in Uremic Pruritus? A Laboratory and Interventional Study.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05634083
Other study ID # RC 22-10-2022
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 25, 2022
Est. completion date January 22, 2023

Study information
Verified date February 2023
Source Benha University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.

Description:

Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied

Recruitment information / eligibility
Status Completed
Enrollment 45
Est. completion date January 22, 2023
Est. primary completion date December 31, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 55 Years
Eligibility Inclusion Criteria: Patients with end-stage renal failure with itching undergoing regular hemodialysis Exclusion Criteria: Patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Uremic pateints with itching
Activated charcoal

Locations
Country Name City State
Egypt Faculty of Medicine, Benha University Al Qalyubiyah Benha
Egypt Benha University Hospitals Banha

Sponsors (1)
Lead Sponsor Collaborator
Benha University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Severity of itching Change of severity of itching by The Visual Analogue Scale score Two months
See also
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