Does Indoxyl Sulfate Have a Role in Uremic Pruritus?

Status Completed

Clinical Trial Summary

Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.

Clinical Trial Description

Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied ;

Study Design

Related Conditions & MeSH terms

Pruritus

Clinical Trial Details

NCT number	NCT05634083
Study type	Interventional
Source	Benha University
Contact
Status	Completed
Phase	N/A
Start date	November 25, 2022
Completion date	January 22, 2023

View Details

See also
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