Proteinuria Clinical Trial
Official title:
Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients
Verified date | August 2020 |
Source | University of Illinois at Chicago |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The goal of this study is to evaluate the benefit of ACTH (Acthar) in reducing proteinuria associated with transplant glomerulopathy in non-diabetic kidney transplant recipients.
Status | Terminated |
Enrollment | 2 |
Est. completion date | September 2015 |
Est. primary completion date | March 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Kidney transplant recipients with confirmed transplant glomerulopathy on kidney biopsy. - Failed standard therapy (>25% reduction in proteinuria) including maximum use of an ACE inhibitor, ARB, or aldosterone blocker with a goal blood pressure less than 130/80 and optimization of their immunosuppression Exclusion Criteria: - Diabetes |
Country | Name | City | State |
---|---|---|---|
United States | University of Illinois at Chicago | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Illinois at Chicago | Mallinckrodt |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 50% Reduction in Proteinuria or Proteinuria < 150mg/Day | 6 months | ||
Secondary | 25% Improvement in the MDRD eGFR | 6 months |
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