Prosthetic Joint Infection Clinical Trial
Official title:
Prospective Cohort of Patients With Prosthetic Joint Infection
Management of prosthetic joint infections (PJI) is a challenging task. These infections include different clinical and microbiological settings calling upon various treatment strategies according to infection type (acute or chronic), bone quality, the involved micro-organism and the patient's general condition and willing. Treatment of PJI combines surgery and prolonged antibiotic therapy. In some patients with a high operative risk prolonged suppressive antibiotic therapy can be used. Lack of large prospective studies motivated the conception of this cohort with a long term follow up, regardless to PJI management procedures.
Large prospective cohort study in a French referral center for bone and joint infections. Population - all patients who consented to participate in the study with PJI treated with: - debridement-synovectomy for acute infection - with one-stage, two-stage exchange arthroplasty for chronic infection - other procedures (complete removal of the prosthesis) and antibiotic therapy - patients (non-operated or operated) receiving prolonged suppressive antibiotic therapy Outcome: - Follow-up at least 2 years - Events monitored: reinfection including relapse and new infection, joint revision for mechanical failure, PJI related or non-related death Study duration: 10 years. Recruitment period: 4 years. Maximal duration of data collection: 6 years. Investigator center: monocenter study. Mean patient inclusion per year: 100 patients per year. ;
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