Propofol Clinical Trial
Official title:
Total Intravenous Anesthesia With Remifentanil-propofol Admixture Using Single-infusion Technique
Background: Application of total intravenous anesthesia (TIVA) may be considered as unpractical when compared with inhalational anesthesia. Although it is mostly not recommended, mixing intravenous agents seems to be popular in clinical practice. The aim of the study was to investigate the possible clinical drawbacks of using remifentanil-propofol admixture (MIXTIVA) for TIVA.
ASA I-II adult patients scheduled for elective thyroidectomy were randomly allocated into 3
groups (n= 32 for each) to have TIVA either with remifentanil and propofol infusions
separately (control group, Group I) or with MIXTIVA infusion that had remifentanil/propofol
proportion 2/1000 or 3/1000 (remifentanil concentration 20 µg/ml or 30 µg/ml in propofol 1%,
Group II or Group III respectively).
This technique may be considered as a practical implementation for busy ambulatory surgery
centers performing general anesthesia, but delayed recovery may be predicted with longer
duration of surgery and anesthesia.
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