Prolymphocytic Leukemia Clinical Trial
Official title:
Phase II Trial of Combined Immunochemotherapy With Fludarabine, Cyclophosphamide and Rituximab in Patients With B-PLL
RATIONALE: Drugs used in chemotherapy, such as fludarabine and cyclophosphamide, work in
different ways to stop the growth of cancer cells, either by killing the cells or by
stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer
growth in different ways. Some find cancer cells and kill them or carry cancer-killing
substances to them. Others interfere with the ability of cancer cells to grow and spread.
Giving fludarabine and cyclophosphamide together with rituximab may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving fludarabine and cyclophosphamide
together with rituximab works in treating patients with B-cell prolymphocytic leukemia.
OBJECTIVES:
- Determine the overall and progression-free survival of patients with B-cell
prolymphocytic leukemia treated with immunochemotherapy comprising fludarabine,
cyclophosphamide, and rituximab.
- Determine the toxic effects of this regimen in these patients.
OUTLINE: This is a non-randomized, open-label, multicenter study.
Patients receive fludarabine IV and cyclophosphamide IV on days 1-3. Patients also receive
rituximab IV on day 0 in course 1 and on day 1 in courses 2-6. Treatment repeats every 28
days for up to 6 courses.
PROJECTED ACCRUAL: A total of 21 patients will be accrued for this study.
;
Allocation: Non-Randomized, Masking: Open Label, Primary Purpose: Treatment
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