Proliferative Thyroid Disease Clinical Trial
Official title:
Diindolymethane: Anti-proliferation Agent in Thyroid Disease—Non-surgical Protocol
Diindolylmethane (DIM), a dietary supplement, found naturally in cruciferous vegetables
(such as cabbage, cauliflower, broccoli, & Brussels sprouts) has been studied extensively in
recent years for its anti-cancer effects. DIM has been shown to exert control over cancer
cell growth in breast, uterine, cervical, ovarian, and colon cancer.
To date no human study has been published regarding the bioavailability of DIM in thyroid
tissue or its effects in proliferative thyroid disease. Our previous study attempted to
elucidate DIM's promotion of anti-proliferative estrogen metabolites in proliferative
thyroid disease and ascertain its uptake in thyroid tissue. DIM has been shown to
concentrate in the thyroid gland. Furthermore, thyroid volumes have been seen to decrease
subjectively.
This study would continue our attempt to elucidate DIM's promotion of anti-proliferative
estrogen metabolites in proliferative thyroid disease.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science