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Clinical Trial Summary

This study aims to investigate if endoscopic trans-sphenoidal prolactinoma resection as a first line treatment, or as an equally valid second line treatment after a short (4-6 months) or long (>2 years) period of pretreatment with a dopamine agonist is superior to standard care for several outcome parameters. The main objectives are to investigate this for quality of life and remission rate. The secondary objectives are to investigate this for biochemical disease control, recurrence rates, clinical symptom control, tumor shrinkage on MRI, pituitary functioning, the occurrence of adverse reactions to treatment, disease burden, and cost-effectiveness.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04107480
Study type Interventional
Source Leiden University Medical Center
Contact Ingrid M Zandbergen, MD
Phone +3171-5296748
Email i.m.zandbergen@lumc.nl
Status Recruiting
Phase Phase 4
Start date June 21, 2019
Completion date March 31, 2026

See also
  Status Clinical Trial Phase
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Not yet recruiting NCT03400865 - Cabergoline Combined Hydroxychloroquine/Chloroquine to Treat Resistant Prolactinomas N/A
Completed NCT00481299 - Insulin Resistance in Women With Prolactinoma N/A
Terminated NCT04106531 - Validation of a Quality of Life Metric "Prolac-10"
Completed NCT01504399 - Rhinological Outcomes in Endonasal Pituitary Surgery
Recruiting NCT03474601 - Seoul National University Pituitary Disease Cohort Study
Completed NCT00697814 - Clomiphene in Males With Prolactinomas and Persistent Hypogonadism Phase 2
Completed NCT05236829 - Exercise Capacity and Physical Activity Level in Prolactinoma Patients
Recruiting NCT03353025 - Study on Therapy of Non-invasive Prolactinoma N/A
Recruiting NCT03457389 - Comparison of Treatment Outcome of Cabergoline According to Target Prolactin Levels in Patients With Prolactinoma N/A
Recruiting NCT01775332 - Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools N/A
Not yet recruiting NCT03717454 - Dopamine D2 Receptors(D2R) Imaging in Prolactinomas N/A
Recruiting NCT00001595 - An Investigation of Pituitary Tumors and Related Hypothalmic Disorders