Progressive Keratoconus Clinical Trial
This is a compassionate treatment protocol for the use of the UV-X system for corneal collagen cross-linking (CXL) in eyes with progressive keratoconus in patients who have conditions that limit their capacity to comply with the cross-linking treatment procedures required by ongoing clinical trials.
This is a non-randomized study. All eyes that qualify for the study will receive the cross-linking (CXL) procedure. Corneal collagen cross-linking is performed as a single treatment. Depending on the patient's condition, the CXL procedure may be performed under sedation or anesthesia. Subjects are followed for 12 months after the procedure to evaluate the long term effects of corneal collagen cross-linking. ;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
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Recruiting |
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Epi-keratoplasty Versus Collagen Cross-Linking in Progressive Keratoconus
|
N/A | |
Completed |
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Stromal Demarcation Line: is it Predictive for Cross-Linking Efficiency?
|
N/A | |
Active, not recruiting |
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Phase 4 | |
Terminated |
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Non-inferiority Trial of Iontophoretic Corneal Collagen Crosslinking (CXL) Compared to Standard Corneal Collagen Crosslinking in Progressive Keratoconus.
|
N/A | |
Recruiting |
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Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus
|
Phase 1/Phase 2 | |
Not yet recruiting |
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Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus
|
Phase 3 | |
Completed |
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Transepithelial Corneal Cross-linking Using Iontophoresis
|
N/A | |
Completed |
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Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin
|
Phase 4 | |
Completed |
NCT04504578 -
Efficacy and Safety ofCACXL in the Treatment of Keratoconus With Thin Corneas
|
N/A | |
Completed |
NCT00647699 -
Corneal Collagen Cross-linking for Progressive Keratoconus
|
Phase 3 | |
Completed |
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Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia
|
Phase 2/Phase 3 | |
Recruiting |
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Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate Keratoconus
|
Phase 3 | |
Recruiting |
NCT04045626 -
Study of Demarcation Line Depth in Transepithelial Versus Epithelium-off Accelerated Cross-linking (AXL) in Keratocouns
|
N/A | |
Completed |
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Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
|
Phase 3 | |
Completed |
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Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus
|
N/A | |
Withdrawn |
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Corneal Crosslinking in Keratoconus and Corneal Ectasia
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Phase 2/Phase 3 |