Prognosis Clinical Trial
Official title:
The Effect of miRNA and Epigenetic Modifications on Prognosis in Covid-19 Infection
NCT number | NCT04411563 |
Other study ID # | 2020/143 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 21, 2020 |
Est. completion date | December 2020 |
The necessity for early detection and hence improving the outcome of treatment of pneumonia is critical especially SARS-CoV-2 induced cases. This work was designed to evaluate the potential application of measuring circulating epigenetic markers namely, miR-744, miR-24, miR-124, miR-155, miR-19a, miR-122, miR-21, miR-223, let-7f, miR-146, miR-196, miR-136, P13-K, miR-9 expression, and DNA methylation profiling of the ACE2, TMPRSS2, PARP, HOX1 genes in Coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 with/without pneumonia and severe acute respiratory syndrome (SARS) patients as an attempt to evaluate the potential benefits of these new circulating, prognostic, epigenetic markers for Turkish patients.
Status | Recruiting |
Enrollment | 105 |
Est. completion date | December 2020 |
Est. primary completion date | September 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - All patients between the ages of 18 and 65 included will suffer from COVID 19, and specific treatment should not yet be initiated. - COVID 19 diagnosis of patients will be based on full medical history, thorough clinical examination, radiological imaging, laboratory assessment, and SARS-CoV-2 analysis by RT-PCR. Exclusion Criteria: - People with chronic lung disease or previous AC surgery - People with immune deficiency or cancer patients - Patients receiving immunosuppressive therapy for autoimmune disease - People with neurological diseases affecting the respiratory muscles, such as hypotonia. |
Country | Name | City | State |
---|---|---|---|
Turkey | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Bakirkoy Dr. Sadi Konuk Research and Training Hospital | Istanbul University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determination of the relationship between the severity of disease and epigenetic factors in COVID 19 | Analysis of pathway-related micro RNAs in patients with mild, moderate and severe Covid 19 clinics | Seven months |
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