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Gastric Acid Suppression and Probiotic Colonization — PR  

Probiotics Clinical Trial

Official title:
The Effect of Gastric Acid Suppression on Probiotic Colonization

Clinical Trial Summary

Probiotics are over-the-counter dietary products with microorganisms that are generally consumed for health benefit. However, the durability of these microorganisms is unclear, particularly when they pass through the highly acidic environment of the stomach. We will test the colonization of these microorganisms among individuals who consume probiotics with and without acid suppression therapy.

Clinical Trial Description

All activities will be related to research. Participants will be randomized to receive either over-the-counter acid suppression medication or placebo from weeks -2 through week 4. All participants will receive VSL #3 (over-the-counter probiotic) from weeks 0 through 4. Survey data, serum, and stool samples will be collected at weeks -2, 0, and 4.

The intervention medication and probiotics have a very low side effect profile and are available over the counter. All data collection methods are non-invasive.

Elucidation of the effects of acid suppression on probiotic colonization will allow us to better understand the utility of probiotics use by individuals on acid suppression medications. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03327051
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase Phase 4
Start date March 20, 2018
Completion date December 30, 2018
View Details
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