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Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study

Primary Open-angle Glaucoma Clinical Trial

Official title:
Assessment of Retinal Photoreceptor Outer Segment Length With Optical Coherence Tomography Before and After Light Stimulation - a Pilot Study

Clinical Trial Summary

It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03921931
Study type Interventional
Source Medical University of Vienna
Contact Doreen Schmidl, MD,PhD
Phone 0043140400
Email doreen.schmidl@meduniwien.ac.at
Status Recruiting
Phase N/A
Start date November 26, 2018
Completion date May 31, 2023
View Details
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