Primary Myelofibrosis Clinical Trial
Official title:
Observatoire Brestois Des Néoplasies Myéloprolifératives
All patients diagnosed or followed in Brest University Hospital for Philadelphia negative
myeloproliferative neoplasms will be included in this observational study.
Myeloproliferative neoplasms recorded included: polycythemia vera, essential Thrombocythemia
and Primary Myelofibrosis.
This is a not interventional study. Alive patients need to sign a non-opposition consent
form.
Patients will be followed until last news (death, change of reference centre...).
In this retrospective and prospective study, clinical and biological data from diagnosis
until last news will be recorded.
Clinical data collected: patients and disease characteristics at the time of the diagnosis,
disease and mutational status, cardio-vascular risk factors, history of thrombosis and
cancer.
Biological data collected: hemogram and bone marrow results if available. During the
follow-up new data will be noted: treatment changes (reasons of change and type of drug),
thrombotic events (localization, date and hemogram), phenotypic evolutions (type and date),
death (date and etiology).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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|
Phase 3 | |
| Not yet recruiting |
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|
Phase 2 | |
| Active, not recruiting |
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|
Phase 2 | |
| Terminated |
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|
Phase 2 | |
| Completed |
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Phase 2 | |
| Completed |
NCT01233921 -
Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer
|
N/A | |
| Unknown status |
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LBH589 (Panobinostat) for the Treatment of Myelofibrosis
|
Phase 1/Phase 2 | |
| Terminated |
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|
Phase 2 | |
| Completed |
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|
||
| Active, not recruiting |
NCT03952039 -
An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib
|
Phase 3 | |
| Active, not recruiting |
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Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia
|
N/A | |
| Completed |
NCT01731951 -
Imetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis
|
Phase 2 | |
| Completed |
NCT01588015 -
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant
|
Phase 1 | |
| Not yet recruiting |
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|
Phase 3 | |
| Completed |
NCT01371617 -
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|
Phase 2 | |
| Active, not recruiting |
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|
Phase 2 | |
| Active, not recruiting |
NCT04446650 -
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|
Phase 1/Phase 2 | |
| Completed |
NCT01981850 -
A Phase 2 Study of RO7490677 In Participants With Myelofibrosis
|
Phase 2 | |
| Withdrawn |
NCT04283526 -
Study of Select Combinations in Adults With Myelofibrosis
|
Phase 1 | |
| Withdrawn |
NCT02584777 -
A Phase II Non-Controlled, Open-Label, Efficacy, Safety, Pharmacokinetic, and Pharmacodynamic Study of Pacritinib in Myelofibrosis
|
Phase 2 |