Primary Insomnia Clinical Trial
Official title:
Information Processing at Sleep Onset and During Sleep in Patients With Insomnia
Chronic insomnia is thought to occur as a result of hyperarousal. While there is a wealth of
data to support this position, there is a lack of research to define how hyperarousal
interferes with sleep initiation, maintenance, and the perception of sleep quality and
quantity. We propose to use Event-related Potential (ERP) techniques to evaluate information
processing at sleep onset and during sleep. ERP measures of information processing have been
well established in good sleepers; they have not been, however, applied to the problem of
insomnia. The goal of the project is to examine the premise that the occurrence and severity
of insomnia is fundamentally related to a neurobiologic preparedness to "attend to" and
"identify" environmental stimuli. Following an extensive screening, patients with insomnia
and good sleepers will participate in two experimental conditions, requiring that they spend
four nights in the sleep laboratory over a two week period. ERP data will be gathered prior
to, following, and during sleep.
The ultimate objectives for this line of research are to determine 1) if insomnia is
associated with a failure to inhibit information processing at sleep onset and/or during
sleep, 2) if the failure to inhibit information processing at sleep onset and/or during
sleep is associated with the occurrence and/or severity of insomnia symptoms, 3) what brain
regions are functioning differently so as to give rise to information processing
abnormalities, and 4) the extent to which pharmacologic and/or Cognitive Behavioral
treatment for insomnia alters information processing abnormalities and/or the associated
brain activity.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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