Primary Hyperparathyroidism Clinical Trial
Official title:
Primary Hyperparathyroidism: Does a Systematic Treatment Improve the Calcium and Bone Metabolism After Successful Surgery in Patients Without Osteoporosis?
Primary Hyperparathyroidism (pHPT) increases bone turnover and resorption and thus calcium
efflux out of bone. After successful surgical treatment of pHPT, bone takes up calcium again
which may result in secondary hyperparathyroidism or even "hungry bone syndrome". Until
today there are no studies about this problem helping to develop recommendations or
guidelines how to prevent these symptoms.
Study hypothesis: Calcium and vitamin D intake after surgery for PHPT protects the bone by
keeping PTH in the normal range (less secondary, reactive hyperparathyroidism), prevents
hungry bone- syndrome and improve bone-turnover markers (osteoporosis protection).
Status | Recruiting |
Enrollment | 80 |
Est. completion date | September 2017 |
Est. primary completion date | September 2017 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Postmenopausal women - Male patients - Biochemically proven PHPT, PTX planned - No evidence for osteoporosis Exclusion Criteria: - Postoperative hypocalcemia needing substitution with calcium and vitamin D/ 1-25-OH-Vitamin D - Cancer (lung, breast, prostatic, parathyroid cancer and thyroid carcinoma >1cm) - Persisting or recurrent PHPT (postoperative hypercalcemia) - Four-gland hyperplasia - Multiple endocrine neoplasia (MEN) or hereditary PHPT - Familial hypercalciuric hypercalcaemia (Ca/creatinine ratio < 0.01) - Phenylketonuria - Renal impairment (creatinine clearance <30ml/h) - Severe hepatic disorder - Severe systemic disorder - Thyroid dysfunction - Immobilisation - Intake of drugs with potential effects on BMD like glucocorticoids, lithium, estrogen-replacement therapy, selective Estrogen-receptor modulators (sERMs), bisphosphonates in the last three months - Intake of drugs containing digoxin or digitoxin - Known allergy against any component of the study medication |
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Austria | Medical University of Vienna | Vienna |
Lead Sponsor | Collaborator |
---|---|
Medical University of Vienna |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Parathyroid hormone | 1 year | No | |
Secondary | BMD of lumbar spine, femoral neck and radius | 1 year | No | |
Secondary | Adverse effects calcium or vitamin D | 1 year | No | |
Secondary | Other biochemical markers of bone metabolism | 1 year | No |
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