Preemptive Analgesia for Primary Dysmenorrhoea

Primary Dysmenorrhea Clinical Trial

Official title:

Preemptive Analgesia for Primary Dysmenorrhoea: a Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03323671
• Other study ID #: 27011975
• Status: Completed
• Phase: Phase 2/Phase 3
• First received: October 27, 2015
• Last updated: December 17, 2017
• Start date: August 1, 2017
• Est. completion date: December 1, 2017

Study information

• Verified date: December 2017
• Source: Mansoura University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Preemptive analgesia before the release of pain mediators

Description:

spasmodic dysmenorrhea is one of the most distressing symptoms in women. adolescents shows a usual absence from school . prostaglandin release is one of the most accepted theory responsible for spasmodic dysmenorrhea.

Non steroidal anti inflammatory Drugs were proved to be one of the alternative medications for spasmodic dysmenorrhea.

Getting the idea of what is called preemptive anesthesia by blocking the receptors before catching pain mediators the study participants will be divided randomly into 2 group group 1 receiving ttt 2 days before the anticipated menstruation and group 2 receiving ttt only during menstruation as analgesia

Recruitment information / eligibility

• Status: Completed
• Enrollment: 84
• Est. completion date: December 1, 2017
• Est. primary completion date: December 1, 2017
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 15 Years to 25 Years

Eligibility

Inclusion Criteria:

• nulliparous ladies

• with regular menstrual cycle pattern

• those experienced history of dysmenorrhea (primary or spasmodic)

• patients able to sallow tables

Exclusion Criteria:

• irregular cycles

• any associated local causes( pelvic infection, endometriosis, fibroid or others)

• patients with familial Mediterranean fever or other intermenstrual attacks of abdominal pain

• gastric or duodenal ulcers or gastritis

• other contraindications to non steroidal anti-inflammatory drugs

• patients with severe diminution of vision or color discrimination

• patients with any depressive or mood disorders

• patients receiving any hormonal treatment

Related Conditions & MeSH terms

• Dysmenorrhea
• Primary Dysmenorrhea

Intervention

Drug:
• preemptive mefenamic acid
preemptive analgesia before menstrual pain
• mefenamic acid
mefenamic acid given only during menstruation

Locations

Country	Name	City	State
Egypt	Mansoura University	Mansourah

Sponsors (1)

Lead Sponsor	Collaborator
Hanan Nabil

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in the Degree of pain	severity of pain according to visual pain analog scale	4 months