Transcranial Electrical Stimulation for Cervical Dystonia

Primary Cervical Dystonia Clinical Trial

Official title: Transcranial Electrical Stimulation (tES) for the Treatment of Cervical Dystonia

Status Completed

Clinical Trial Summary

There are two phases.

Phase I: A single visit which includes a screening, clinical scales, and a MRI scan with simultaneous tES/sham tES in a randomized block design. Enrolls both Cervical Dystonia (CD) patients and healthy controls.

Phase II: 5 consecutive days of 30-90 min visits to campus for tES or sham tES. Transcranial magnetic stimulation (TMS) measures and clinical scales will also be included on Day 1 and Day 5 visits. Enrolls only CD patients.

Clinical Trial Description

Phase I:

Enrolls both CD patients and healthy controls.

One approximately 3 hour visit which includes:

• a screening & neurological exam,

• clinical scales & questionnaires,

• a (approx.) 60 min MRI scan with simultaneous tES/sham tES in a randomized block design and EMG

Phase II:

Enrolls only CD patients.

Five consecutive days of study visits.

Day 1:

• TMS screening,

• repeated neurological assessment and clinical scales if >1 month since MRI visit

• 30 min TMS session with concurrent EMG

• 20 min tES or sham tES session

Days 2-4:

• 20 min tES or sham tES session

Day 5:

• 20 min tES or sham tES session

• 30 min TMS session with concurrent EMG

• repeated neurological assessment and clinical scales ;

Related Conditions & MeSH terms

• Dystonia
• Dystonic Disorders
• Primary Cervical Dystonia
• Torticollis

• NCT number: NCT03369613
• Study type: Interventional
• Source: University of Colorado, Denver
• Status: Completed
• Phase: N/A
• Start date: October 27, 2017
• Completion date: September 20, 2021