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Gut Microbes and Metabolic Group in Different PBC Patients for UDCA Response

Primary Biliary Cirrhosis Clinical Trial

Official title:
A Clinical Study About Gut Microbes and Metabolic Group in Different PBC Patients for UDCA Response

Clinical Trial Summary

To compare intestinal flora diversity in different PBC patients with UDCA responses, and further study the differences of bile acid metabolism and short chain fatty acid metabolism in feces and serum of two groups of PBC patients.

Clinical Trial Description

The PBC patients have been enrolled in the study for UDCA treatment more than 1 year, who is divided into the UDCA total response Group and the other poor response group according to Paris-I/II standard .The feces of two groups of patients were collected and the differences of microbial polymorphism of fecal microorganism in two groups were observed. The metabolic differences of bile acids and short chain fatty acids in serum and feces of two groups of PBC patients were studied by means of metabolic proteomics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03590886
Study type Observational [Patient Registry]
Source Sun Yat-sen University
Contact
Status Completed
Phase
Start date August 22, 2018
Completion date February 28, 2019
View Details
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