Primary Aldosteronism Clinical Trial
Official title:
Preoperative Supine Time for Adrenal Venous Sampling: A Prospective Randomized Controlled Trial
This study aim to understand whether the length of preoperative supine time would affect the AVS outcome.
Primary aldosteronism (PA) is the most common form of secondary hypertension, accounting for 5% of hypertensive patients and 17-23% in patients with resistant hypertension. Compared to the primary hypertension, PA is more prone to cause severe organ damage and even early death. Adrenal venous sampling (AVS) is an effective confirmatory test for subtyping unilateral and bilateral adrenal hyperplasia, helping doctors to make an accurate decision between surgery or medication. Supine in bed before AVS is recommended for a desirable result of AVS according to guidelines. However, investigating study about the most optimal preoperative supine time before AVS is lacking. This is a single-center prospective randomized controlled study. 120 patients diagnosed as PA and with willing for further AVS examination will be included. Participants will be randomly allocated to 15-min supine time group or 2-hours supine time group. The primary outcomes are the degrees of clinical and laboratory remission (blood pressure, type and dose of antihypertensive drugs, serum potassium, orthostatic ARR). The secondary outcomes are the technical success rate and adverse event of AVS (selective index≥2 is considered as successful surgery without corticotropin stimulate). Discussion: Primary aldosteronism is an intractable public health problem, and many techniques including AVS have been developed to correctly identify this disease. This study will help to understand whether the length of preoperative supine time would affect the diagnostic efficacy of AVS, and thus help to formulate a more reasonable AVS procedure. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02885662 -
Study of CS-3150 in Patients With Primary Aldosteronism
|
N/A | |
Withdrawn |
NCT02096939 -
Microvascular Function in Primary Aldosteronism
|
N/A | |
Completed |
NCT01728493 -
Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
|
N/A | |
Recruiting |
NCT06228677 -
Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization
|
||
Recruiting |
NCT06047912 -
Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
|
||
Recruiting |
NCT04991961 -
Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Screening for Primary Aldosteronism
|
||
Recruiting |
NCT05501080 -
The Effect of SAAE on Ventricular Remodeling in PA Patients
|
N/A | |
Recruiting |
NCT05405101 -
Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA
|
N/A | |
Recruiting |
NCT05973604 -
Prevalence of Primary Aldosteronism in Atrial Fibrillation
|
||
Recruiting |
NCT05826080 -
Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism
|
||
Completed |
NCT04179019 -
Calcium Channel Blockade in Primary Aldosteronism
|
Phase 2 | |
Completed |
NCT03500120 -
Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism
|
||
Recruiting |
NCT04213963 -
Prospective Study on Primary Aldosteronism in Resistant Hypertension
|
||
Completed |
NCT05435703 -
Renal Cysts and Primary Aldosteronism
|
||
Recruiting |
NCT02945904 -
IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism
|
||
Enrolling by invitation |
NCT02257450 -
Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study
|
N/A | |
Recruiting |
NCT05561361 -
The Effect of SAAE on Vascular Endothelial Function in PA Patients
|
||
Completed |
NCT03398785 -
Adrenal Artery Ablation Treats Primary Aldosteronism
|
Phase 3 | |
Recruiting |
NCT03224312 -
Chongqing Primary Aldosteronism Study
|
||
Recruiting |
NCT04428827 -
Outcome of Patients With Primary Aldosteronism
|