Preterm Labor Clinical Trial
Official title:
The Role of Cyclin-dependent Kinase Inhibitor 2A (P16 INK4a) (Placental Senescence Marker) on Labor-related Signals Through Progesterone Receptors Expression in Human Placenta
Onset of labor in human is initiated by progesterone withdrawal. Over many decades researchers had proposed hypotheses to explain the functional withdrawal of progesterone. These hypotheses were through the sequestration of active progesterone by corticosteroid-binding globulin, a decrease in active progesterone metabolite levels and changes in the ratio of progesterone receptor (PR) isoforms (nuclear progesterone receptors A (nPRA) and nuclear progesterone receptors B (nPRB)). Progesterone performs its action non-genomically through binding to membrane receptors and genomically via binding to nPRs. PRA is the less active or inactive form of progesterone receptors and shorter in amino acid sequence than PRB, the active form of the receptors.
Status | Not yet recruiting |
Enrollment | 81 |
Est. completion date | February 2025 |
Est. primary completion date | September 2024 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Pregnant women who will come for termination of pregnancy by caesarean section or vaginal delivery. - Gestational age is between 28 to < 37 weeks for preterm labor and 37 to 40 weeks for term labor. - The age range of women is between18- 40 years. Exclusion Criteria: - Acute or chronic infectious diseases or other chronic illness - Autoimmune diseases - PE complicated with Eclampsia, DIC or HELP syndrome - Congenital anomaly of the uterus - History of trauma - Twins pregnancy - Congenital anomalies of the fetus - Fetal growth restriction |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
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Kumari R, Jat P. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front Cell Dev Biol. 2021 Mar 29;9:645593. doi: 10.3389/fcell.2021.645593. eCollection 2021. — View Citation
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Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | P16 INK4a | 1.Evaluating the role of cyclin-dependent kinase inhibitor 2A (P16 INK4a) placental senescence marker to predict time of labor. | one year | |
Secondary | PR | 2.Local effect of cyclin-dependent kinase inhibitor 2A (P16 INK4a) placental senescence marker on progesterone receptors expression in human placenta. | one year |
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