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Perenteral Nutrition and Oxidative Stress in Preterm Infants

Preterm Infants Clinical Trial

Official title:
Study of the Oxidant-Antioxidant Effects of Parenteral Nutrition in Preterm Neonates

Clinical Trial Summary

In an effort to decrease the load of peroxides in TPN solutions, multiple studies examined different strategies such as photo-protection, adding multivitamins to the lipid emulsion rather than to the dextrose-amino acid admixture, and adding antioxidants such as glutathione to the TPN solution. However, the role of trace elements as antioxidants, and their interaction with light have not been studied. Also, the impact of TPN-related oxidants on clinical morbidities has not been addressed. Therefore, we aimed in this study of preterm infants to evaluate the role of different components of TPN on urinary peroxides and to examine the biochemical and clinical effects of light protection.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00611546
Study type Interventional
Source Mansoura University
Contact
Status Completed
Phase N/A
Start date April 2003
Completion date January 2005
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