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Gut Microbiota of Preterm Infants and Full-term Infants at Early Life

Preterm Infant Clinical Trial

Official title:
Gut Microbial Succession of Preterm Infants and Full-term Infants at Early Life

Clinical Trial Summary

The aim of this study is to obtain a longitudinal view of the gut microbial establishment of a cohort of 51 preterm (PT) infants compared to 50 full-term (FT) infants from birth to 90 days of age, and to identify key clinical factors that affect the establishment of neonatal microbiome. The hypothesis of the investigators is that the gut microbiota progression of PT group and FT group is different in diversity and composition. Antibiotics and its usage duration is likely the main factor disturbing the colonization and development of the gut microbiome of PT infants.

Clinical Trial Description

Premature birth is a global clinical problem. Early colonization and development of the neonatal gut microbiome is critically important with a profound impact on the host lifelong health. V3-V4 region of 16S rRNA amplicons of 581 stool DNA will be sequenced from a cohort of 51 PT infants and 50 FT infants to examine the microbial profiles. A random-effects generalized least square regression model is used to compare the difference in the main bacterial groups over time with the adjustment for multiple variables including gestational age and use of antibiotics . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03373721
Study type Observational
Source Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Contact Jie Jia, PhD
Phone 0086-13122322289
Email jie.jia@shsmu.edu.cn
Status Recruiting
Phase
Start date July 20, 2014
Completion date December 20, 2028
View Details
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