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RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix — SCAN  

Preterm Delivery Clinical Trial

Official title:
A Randomized Trial of 17 Alpha-Hydroxyprogesterone Caproate for Prevention of Preterm Birth in Nulliparous Women With a Short Cervix

Clinical Trial Summary

The purpose of this study is to see if giving progesterone medication to pregnant women, who have never delivered a baby after 19 weeks of pregnancy and who have a short cervix, lowers the risk of early delivery and improves the health of their baby.

Clinical Trial Description

Preterm births, defined as the delivery of a baby less than 37 weeks of gestation, are responsible for the majority of neonatal mortality and morbidities. Studies have shown that a number of risk factors, including never having a baby before and having a short cervix are associated with early delivery. Recently the NICHD did a study in women who were pregnant again after having delivered preterm. It showed that giving 17 alpha-hydroxyprogesterone caproate (17P) medication during pregnancy decreased the chance of delivering another preterm baby by 34%. This placebo-controlled randomized clinical trial will address the primary research question: does treatment with 17P initiated before 23 weeks of gestation prevent delivery prior to 37 weeks in nulliparous women with a singleton gestation who have a short cervix? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00439374
Study type Interventional
Source The George Washington University Biostatistics Center
Contact
Status Terminated
Phase Phase 3
Start date April 2007
Completion date December 2011
View Details
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