Presbycusis Clinical Trial
— MITOPRESOfficial title:
Mitochondrial Genetics of Presbycusis
NCT number | NCT03720964 |
Other study ID # | 49RC18_0148 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | April 2019 |
Est. completion date | November 2023 |
The main goal of this study is to identify mitochondrial mutations associated with presbycusis. Patients affected by severe presbycusis and normal hearing controls (according to ISO7029 norm) will be enrolled if satisfying inclusion criteria (aged from 40 to 80 years old) in existing biocollections in the University Hospital of Angers. After DNA extraction, the mitochondrial genome will be sequenced and data in silico analysed.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | November 2023 |
Est. primary completion date | November 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 80 Years |
Eligibility |
Inclusion Criteria: - age related hearing loss more severe than the predicted hearing thresholds according to the norm ISO7029, for the presbycusis population; - normal hearing according to norm ISO7029 for the control population Exclusion Criteria: - deafness diagnosed before 40 years old - exclusion criteria of one of the biocollection |
Country | Name | City | State |
---|---|---|---|
France | UH Angers | Angers |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Angers |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | identification of clinical features predicting some presbycusis forms | analysis of audiometric data after genetic analysis will be performed | the analysis will be conducted at the end of the inclusion of the 200 patients | |
Primary | identification of mitochondrial mutations associated with presbycusis | Enrichment analysis will be perfomed with CHI2 test after Benjamini correction. | the analysis will be conducted at the end of the inclusion of the 200 patients | |
Secondary | identification of genomic variants associated with presbycusis | enrichment of genomic variants will be analysed | the analysis will be conducted at the end of the inclusion of the 200 patients | |
Secondary | identification of DNA variants associated with environmental susceptibility | subgroup analysis will be performed in accordance with environmental exposition | the analysis will be conducted at the end of the inclusion of the 200 patients |
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