Presbycusis Clinical Trial
Official title:
Mitochondrial Genetics of Presbycusis
The main goal of this study is to identify mitochondrial mutations associated with presbycusis. Patients affected by severe presbycusis and normal hearing controls (according to ISO7029 norm) will be enrolled if satisfying inclusion criteria (aged from 40 to 80 years old) in existing biocollections in the University Hospital of Angers. After DNA extraction, the mitochondrial genome will be sequenced and data in silico analysed.
The study will be proposed to patients consulting in the ENT department of the University
Hospital of Angers. After clinical examination and audiometry recording, the eligibility
criteria will be checked and inclusion in biocollections proposed. Presbycusis affected
subjects will be enrolled in "Mitochondrial Disease biocollection" and normal hearing
controls in "Healthy Volunteer biocollection". These biocollections have been approved by the
board comitee "Centre de Protection des Personnes".
After DNA extraction and mitochondrial sequencing, candidate variants will be selected by in
silico analysis. The presence of mitochondrial variants in both groups (presbycusis and
control) will be compared in multivariate analysis if needed.
The nuclear DNA may be sequenced in order to complete the previous analysis and look for any
candidate variant .
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04601909 -
FX-322 in Adults With Age-Related Sensorineural Hearing Loss
|
Phase 1 | |
Completed |
NCT04030299 -
Longitudinal Outcomes of Hearing Aids
|
N/A | |
Enrolling by invitation |
NCT02729402 -
Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults
|
N/A | |
Completed |
NCT01788423 -
Evaluating Hearing Aid Service Delivery Models
|
N/A | |
Completed |
NCT00371449 -
Predicting Success With Hearing Aids
|
N/A | |
Recruiting |
NCT04360109 -
Study of the Association Between Presbycusis With the Incidence of Frailty
|
||
Completed |
NCT00488007 -
Clinical Trial on Alzheimer Disease, Presbycusis and Hearing Aids
|
N/A | |
Enrolling by invitation |
NCT03101722 -
Effects of Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD)
|
N/A | |
Recruiting |
NCT04923087 -
Impact of Auditory Stimulation in Eating Pleasure (EDERE 2021)
|
||
Completed |
NCT02448706 -
Variability In Hearing Aid Outcomes In Older Adults
|
N/A | |
Completed |
NCT01950013 -
At-home Auditory Training Clinical Trial
|
N/A | |
Recruiting |
NCT05125081 -
Efficacy and Safety of Liuwei Dihuang Pill Versus Placebo in Presbycusis With Shen (Kidney)-Yin Deficiency
|
Phase 2 | |
Not yet recruiting |
NCT06183450 -
Hearing and Cognition in Aging Adults
|
||
Completed |
NCT04200664 -
Audiovestibular Function in Infratentorial Superficial Siderosis
|
||
Completed |
NCT03579563 -
Cost-effective Hearing Aid Delivery Models
|
N/A | |
Completed |
NCT03638323 -
Age-related Hearing Loss and Lexical Disorders
|
||
Completed |
NCT01732289 -
Genetic Study of Age Related Hearing Loss
|
Phase 0 | |
Completed |
NCT02147847 -
Computer-Based Auditory Rehabilitation
|
N/A |