Prematurity Clinical Trial
Official title:
Development and Use of a Tissue and Human Enteroid Biorepository to Study the Pathophysiology of Neonatal Necrotizing Enterocolitis
Despite a greater understanding of NEC physiopathology, modest progress has been done in
terms of intervention and prevention of the disease over the past three decades, being the
mortality rate unchanged.
Investigators intend to leverage our knowledge and technical expertise developed with fetal
enteroids to further investigate the processes leading to NEC by deriving and performing
functional studies on human intestinal enteroids generated from intestinal resection for
therapeutic reasons in NEC and non-NEC patients
1. Generate a tissue biorepository composed of: enteroids and other lamina propria cells
2. Comparative studies of the gene expression profile of tissue, epithelial enteroids and
underlying lamina propria of NEC, non-NEC, hypoxic and non-hypoxic infants
3. In vitro functional studies for the evaluation of critical factors in NEC
pathophysiology
4. In vitro functional studies to identify the activation of processes leading to
intestinal epithelium necroptosis and/or apoptosis in bacteria challenged and hypoxic
conditions
5. Correlative studies of the impact of perinatal variables on the intestinal barrier
functionality at baseline and challenged with pathogens
6. In vitro comparison of the intestinal barrier functionality in infants complicated by
condition of prenatal hypoxia versus non hypoxic infants
7. Validation the NEC enteroids as an in vitro model for the identification of treatments
and prevention of NEC
n/a
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