Metformin for the Treatment of Premature Pubarche in Girls

Premature Pubarche Clinical Trial

Official title: A Double Blind Randomized Controlled 12 Month Trial of Metformin for the Treatment of Premature Pubarche in Girls

Status Terminated

Clinical Trial Summary

The primary objective of this study is to determine the safety and efficacy of metformin in lowering serum DHEAS levels in girls with premature pubarche and secondary, to observe changes in hormones associated with pubertal development including gonadotropins, sex steroids, insulin, adipocytokines, and growth factors.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Premature Birth
• Premature Pubarche
• Puberty, Precocious

• NCT number: NCT01316042
• Study type: Interventional
• Source: Milton S. Hershey Medical Center
• Status: Terminated
• Phase: N/A
• Start date: May 2011
• Completion date: April 2014