Premature Ovarian Failure Clinical Trial
Official title:
Ovarian Histopathology and Laparoscopic Assessment of Premature Ovarian Failure and Its Relation to Thyroid Dysfunction
25 women with Premature Ovarian Failure who attended Fayoum university hospital gynecology
outpatient clinic (case group) and another group of 25 women with normal ovarian function
(control group).
*Pelvic laparoscopy and ovarian biopsy will be done ovarian biopsy preparation
For assessment of autoimmune oophoritis, sections were immunostained with anti-LCA (CD45)
monoclonal antibody
25 women with Premature Ovarian Failure who attended Fayoum university hospital gynecology
outpatient clinic (case group) and another group of 25 women with normal ovarian function
(control group).Pelvic laparoscopy and ovarian biopsy To be examined histologically. All
procedures were performed under general anesthesia the utero-ovarian ligament was stabilized
with the round biopter introduced through the other. The round metal biopter 5 mm in diameter
with an inner protective trocar.
The tip of the biopsy instrument was placed on an area of the ovary free of cysts; the hilar
area was avoided because it is deficient in small follicles. After correct placement was
verified, the inner protecting trocar was removed to expose the sharp leading edge of the
round sheath. Gentle circular movements were made cutting through the ovarian cortex to
produce a 5-mm disk of 2-3 mm in thickness. The round biopter was removed, and a grasper was
introduced to recover the excised tissue.
Ovarian biopsy specimens were fixed in 10% formalin and embedded in paraffin forming tissue
blocks. Two sections, 4μ thick were cut from each block. One was stained with routine
haematoxylin and eosin (H&E) stain while the other was immunostained with anti-Leukocyte
Common Antigen (LCA).
For assessment of autoimmune oophoritis, sections were immunostained with anti-LCA (CD45)
monoclonal antibody
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