Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF

Status Completed

Clinical Trial Summary

Cellular therapies are rapidly progressing fields and have shown immense promise in the treatment of damaged ovarian function. The purpose of this study is to determine safety and efficacy of intra-ovarian injection of allogeneic HUC-MSCs with injectable collagen scaffold in women with Premature Ovarian Failure (POF) and to study the preliminary efficacy of HUC-MSCs with injectable collagen scaffold injection on ovarian function improvement.

Clinical Trial Description

The purpose of this study was to explore the therapeutic potency of the HUC-MSCs with injectable collagen scaffold transvaginal injection for POF women. The serum of each patient was kept and sent for laboratory test before the surgery. HUC-MSCs were isolated and cultured in vitro and the biomarkers of HUC-MSCs were detected using Flow cytometry detection. The HUC-MSCs with injectable collagen scaffold were then injected directly into bilateral ovaries. The outcomes of patients were examined after the injection. The patients are monitored for signs of follicle growth and growing follicles are stimulated with exogenous hormones, followed by oocyte retrieval and In Vitro Fertilization (IVF). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02644447
Study type	Interventional
Source	Chinese Academy of Sciences
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	October 2015
Completion date	October 2018

View Details

See also
Status	Clinical Trial	Phase
Unknown status	`NCT01853501` - Effects of ADSC Therapy in Women With POF	Phase 4
Completed	`NCT00417066` - Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders	Phase 4
Active, not recruiting	`NCT04675970` - Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy
Recruiting	`NCT03480412` - Second Step Protocol in Poor Ovarian Responder (POR)
Completed	`NCT03840824` - Blood Spot Self-administered Test and Assay
Recruiting	`NCT00119925` - 'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"	N/A
Recruiting	`NCT06117982` - The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency	Phase 2
Suspended	`NCT03816852` - The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiency	Phase 2
Not yet recruiting	`NCT04390308` - Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Completed	`NCT02783937` - Filgrastim for Premature Ovarian Insufficiency	Phase 4
Completed	`NCT00295087` - X-Chromosome Inactivation Status and Premature Ovarian Failure	N/A
Completed	`NCT00429494` - GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients	Phase 2
Not yet recruiting	`NCT05522634` - A Clinical Study of Chinese Herbal Compound TJAOA101 in the Treatment of Premature Ovarian Insufficiency	Early Phase 1
Recruiting	`NCT05838157` - The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age
Withdrawn	`NCT01129947` - The Use of DHEA in Women With Premature Ovarian Failure	Phase 0
Completed	`NCT00001275` - Ovarian Follicle Function in Patients With Primary Ovarian Failure	N/A
Not yet recruiting	`NCT04306185` - Ovarian Fragmentation Study (Crespo Medical Team)	N/A
Recruiting	`NCT02062931` - Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure	Phase 1/Phase 2
Completed	`NCT02372474` - "It is a Real" The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian Failure	Phase 1/Phase 2
Completed	`NCT02151890` - Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure	Phase 1/Phase 2