Premature Ovarian Failure Clinical Trial
Official title:
Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure (POF)
Out of 112 high risk patients for Premature Ovarian Failure (POF), diagnosis was established
in 10 cases.
ESS cut off point for menstruation and pregnancy was 6.
Out of 112 high risk patients for POF, diagnosis was established in 10 cases. Endometrial
fractional biopsy was taken, stained with H&E stain and by immubohistchemical (IH) staining
by stem cell marker OCT4. IH expression of stem cell marker OCT4 was evaluated before and
after transplantation according to Edessy Stem Cell Score (ESS).
After laparoscopic injection of stem cell sample in the ovaries, participants were followed
up monthly for a period of one year by hormonal (FSH, LH and E2), clinical (resuming
menstruation), US (folliculometry), histopathological (HP), and IH expression of stem cell
(stem cell positivity and scoring according to ESS).
These cases were of ESS 5 and 6.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Unknown status |
NCT01853501 -
Effects of ADSC Therapy in Women With POF
|
Phase 4 | |
Completed |
NCT00417066 -
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
|
Phase 4 | |
Active, not recruiting |
NCT04675970 -
Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy
|
||
Recruiting |
NCT03480412 -
Second Step Protocol in Poor Ovarian Responder (POR)
|
||
Completed |
NCT02644447 -
Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF
|
Phase 1/Phase 2 | |
Completed |
NCT03840824 -
Blood Spot Self-administered Test and Assay
|
||
Recruiting |
NCT00119925 -
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
|
N/A | |
Recruiting |
NCT06117982 -
The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency
|
Phase 2 | |
Suspended |
NCT03816852 -
The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiency
|
Phase 2 | |
Not yet recruiting |
NCT04390308 -
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
|
||
Completed |
NCT02783937 -
Filgrastim for Premature Ovarian Insufficiency
|
Phase 4 | |
Completed |
NCT00295087 -
X-Chromosome Inactivation Status and Premature Ovarian Failure
|
N/A | |
Completed |
NCT00429494 -
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
|
Phase 2 | |
Not yet recruiting |
NCT05522634 -
A Clinical Study of Chinese Herbal Compound TJAOA101 in the Treatment of Premature Ovarian Insufficiency
|
Early Phase 1 | |
Recruiting |
NCT05838157 -
The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age
|
||
Withdrawn |
NCT01129947 -
The Use of DHEA in Women With Premature Ovarian Failure
|
Phase 0 | |
Completed |
NCT00001275 -
Ovarian Follicle Function in Patients With Primary Ovarian Failure
|
N/A | |
Not yet recruiting |
NCT04306185 -
Ovarian Fragmentation Study (Crespo Medical Team)
|
N/A | |
Recruiting |
NCT02062931 -
Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
|
Phase 1/Phase 2 | |
Completed |
NCT02372474 -
"It is a Real" The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian Failure
|
Phase 1/Phase 2 |