Premature Birth Clinical Trial
Official title:
Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Compare the bacterial digestive microbiota during the stay in neonatal intensive care between a group of premature newborns developing a NEC (necrotizing enterocolitis) and a group of newborns free from NEC.
Monitoring of a cohort of premature newborns with constitution of a collection of biological samples. follow-up of newborns from birth up to 37 weeks of amenorrhea. The medical care of children will not be affected by their participation in the research. - Sampling of amniotic fluid at the time of rupture of the water bag - Sampling of the blood contained in the umbilical cord after clamping and section of the cord - Sampling of meconium during the first 24 hours of life in intensive care / neonatal / maternity ward - Collection of a daily stool sample until the end of hospitalization and when a NEC occurs - Sampling of gastric residues during an episode of NEC - Taking a daily sample of the newborn's enteral food - Sampling of 500 µL of additional blood weekly during the punctures made for the treatment - Daily statement of constants - Record of all complications related to prematurity (HIV, bronchodysplastic, sepsis) - Blood analysis: CBC, platelets and CRP (data analyzed as part of the treatment). Specific analyzes for research will assess: the level of tryptase, IL4 and TLR4. The samples will be stored and analyzed in the immunology laboratory of the CHU Clermont Ferrand (Pr B. Evrard) - Analysis of the meconium sample and each stool emitted during hospitalization, and during an episode of ECUN ;
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