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ADMA and Mechanical Ventilation in Preterm Infants

Premature Birth Clinical Trial

Official title:
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants

Clinical Trial Summary

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

Clinical Trial Description

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning. ;

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00460044
Study type Observational
Source VU University Medical Center
Contact
Status Completed
Phase N/A
Start date January 2002
Completion date July 2003
View Details
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