Premature Baby 25 to 32 Weeks Clinical Trial
Official title:
Cerebral Abnormalities Detected by MRI, Realized at the Age of Term and the Emergence of Executive Functions
The survival of premature babies increased during the last decades. However, the
neurocognitive long term development of these children is worrying, as demonstrated by
EPIPAGE 1 study.
These children present high risk of deficits such as cognitive deficits, adaptive
malfunction, behavior disorders and difficulties in school learning.
Understanding the specific neuropsychological disorders at the origin of these deficits is
an important objective. Studies realized at school age showed that many premature children
have executive functions (EF) disorders. However the specific nature of these disorders and
the neuropathology associated are unknown.
The aim of this study is to realise MRI at term age in preterm babies born less than 32 GA
and to correlate MRI findings with executives functions and neurodevelopmental outcome
An MRI would be realized between 39 and 41 GA
At the age of 5 years, executive functions and neurodevelopmental testing would be realized.
600 newborns were recruited.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic