Pregnancy Outcome Clinical Trial
Official title:
The Effect of Cervical Morphological Changes on Pregnancy Outcome After Loop Electrosurgical Excision Procedure
This study aims to assess how the proportion of the cervical volume/length removed during treatment for cervical intraepithelial neoplasia (CIN) varies and whether this correlates to the pregnancy duration at delivery
The high peak age of the Cervical intraepithelial neoplasia (CIN)patients was from 25 to 35
years old, which is the best women of childbearing age, Standard treatment for CIN is called
Loop electrosurgical excision procedure (LEEP),but the inappropriate conization may damage
the cervical function leading to infertility, abortion, preterm delivery and dystocia.
Therefore, reasonable and standard conization is very important for treating and preventing
the complication. The International Federation of Cervical Pathology and Colposcopy(IFCPC)
advocates the length of cervical conization should be decided by the type of cervical
transformation zone, however, the cervical lengths in female are different leading to the
same cervical conization lengths cause the diverse influences on the cervical
function.Therefore, individualized cervical conization therapies are very needed,At present,
there are still lack of objective data about cervical morphology of women at childbearing
age,besides the effects of cervical morphological changes caused by LEEP on pregnancy and
childbirth has not been reported.
Our hypothesis is that the proportion of the cervical tissue removed is likely to influence
both cervical healing and the cervical volume following surgery and as a result the risk of
prematurity in subsequent pregnancies. The present prospective study investigates the
variation in the proportion of the cervix removed during excisional treatment and provides
pilot data on pregnancy outcomes in a sample population for which the dimensions and
proportions of the cervical tissue excised are assessed at the time of treatment.
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