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Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease

Preclinical Alzheimer's Disease Clinical Trial

Official title:
Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease

Clinical Trial Summary

The purpose of this study is to assess the safety and efficacy of gemfibrozil in modulating microRNA-107 levels for the prevention of Alzheimer's disease in subjects with intact cognition and mild cognitive impairment

Clinical Trial Description

Double-blind, placebo controlled, parallel-design. 48 cognitively-intact subjects, and 24 subjects with early cognitive decline (CDR 0.5) will be randomly assigned to treatment with gemfibrozil (600 mg orally twice a day) or placebo for 52 weeks. Safety assessments will include routine assessment of adverse events, safety labs, and brain magnetic resonance imaging. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02045056
Study type Interventional
Source University of Kentucky
Contact
Status Completed
Phase Early Phase 1
Start date May 2014
Completion date June 2019
View Details
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