Preclinical Alzheimer's Disease Clinical Trial
Official title:
Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease
The purpose of this study is to assess the safety and efficacy of gemfibrozil in modulating microRNA-107 levels for the prevention of Alzheimer's disease in subjects with intact cognition and mild cognitive impairment
Double-blind, placebo controlled, parallel-design. 48 cognitively-intact subjects, and 24 subjects with early cognitive decline (CDR 0.5) will be randomly assigned to treatment with gemfibrozil (600 mg orally twice a day) or placebo for 52 weeks. Safety assessments will include routine assessment of adverse events, safety labs, and brain magnetic resonance imaging. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06033066 -
Financial Incentives and Recruitment to the APT Webstudy
|
N/A | |
Enrolling by invitation |
NCT06416072 -
Alzheimer's Plasma Extension
|
||
Recruiting |
NCT04851496 -
Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - PAST Extension
|
||
Terminated |
NCT04846426 -
Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - FUTURE Extension
|
||
Completed |
NCT04828122 -
Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech
|
||
Completed |
NCT03370744 -
Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD
|
||
Completed |
NCT02963415 -
Concurrent Aerobic Exercise and Virtual Reality Cognitive Training
|
N/A | |
Active, not recruiting |
NCT04004767 -
TRC-PAD Program: In-Clinic Trial-Ready Cohort
|
||
Recruiting |
NCT04468659 -
AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
|
Phase 3 | |
Recruiting |
NCT04937959 -
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - PAST Extension
|
||
Completed |
NCT04928976 -
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping
|
||
Terminated |
NCT04951284 -
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - FUTURE Extension
|