Pre-Term Clinical Trial
Official title:
Inter-personal Brain Coupling Between Preterm Infants, Their Parents and a Musician During Creative Music Therapy Using Functional Near-infrared Imaging (fNIRI) Hyperscanning
Inter-personal brain coupling between preterm infants, their parents and a musician during Creative Music Therapy using functional near-infrared imaging (fNIRI) hyperscanning and systemic physiology measurements
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 32 Weeks to 36 Weeks |
Eligibility | Inclusion Criteria: - Clinically stable preterm infants (no invasive cardiovascular or ventilation support) - age: 7-21 days of life - born with 32 0/7 = 36 6/7 weeks of gestation - mentally stable parents of the included infants Exclusion Criteria: - admission for palliative care - congenital malformation - parental psychiatric disorders - parental language barriers |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital Zurich | Zürich |
Lead Sponsor | Collaborator |
---|---|
University of Zurich |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Inter-personal synchronization of cerebral oxygenation and hemoglobin concentration | Inter-personal synchronization (determined by the time-dependent coherence calculated via Wavelet transform coherence) of cerebral oxygenation (StO2 in %) and total hemoglobin concentration ([tHb] in relative µM) time-series in the brain between the infant and the parent as well as the infant and the music therapist measured by functional near-infrared spectroscopy (fNIRS) neuroimaging with a commercially available device approves for clinical applications (OxyPrem) in the left auditory and prefrontal cortex. Both devices provide similar measurements of cerebral oxygenation and hemodynamics, i.e. relative changes in the concentration of oxyhemoglobin ([O2Hb] in relative µM) and deoxyhemoglobin ([HHb] in relative µM). These time-series will be first pre-processed (removal of artifacts, band-pass filtered (0.01-0.5 Hz)) and then analyzed (Wavelet coherence and subsequent statistical analysis via a generalized additive model and Bayesian analysis). | 50 minutes |
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