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NCT04463940 Clinical Trial

Xanthine Oxidase and Uric Acid Origin in Preeclamptic Women

Pre-Eclampsia Clinical Trial

Official title:
The Origin of Xanthine Oxidase and Its Metabolite, Uric Acid, in Preeclamptic Pregnant Women - A Pilot Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04463940
Other study ID # 0024-19-BRZ
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 30, 2020
Est. completion date August 2024

Study information
Verified date July 2022
Source Barzilai Medical Center
Contact Yaniv Ovadia, Dr
Phone + 972 (0) 8 6745220
Email yanivo@bmc.gov.il
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Findings regarding the presence of xanthine oxidase and uric acid in different blood locations is important in preeclamptic women. We aim to detecting Xanthine oxidase and uric acid levels in both umbilical cord artery and vein as well as maternal blood (3 "locations") in pregnant women with and without diagnosis of preeclampsia. The study population will be divided into groups matching the three "locations" in order to describe and compare outcome levels.

Description:

Significance - findings regarding the presence of xanthine oxidase and uric acid in different blood locations may provide a scientific basis for understanding the source of them in preeclamptic women. Aim - detecting Xanthine oxidase and uric acid levels in both umbilical cord artery and vein as well as maternal blood (3 "locations"). Methods - samples will be collected from pregnant women with and without diagnosis of preeclampsia with blood uric acid > 6 mg/dL. Than the study population will be divided into groups matching the three "locations". The investigators will describe and compare outcome levels (including Xanthine oxidase, uric acid).

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date August 2024
Est. primary completion date August 2023
Accepts healthy volunteers
Gender Female
Age group 20 Years to 55 Years
Eligibility Inclusion Criteria: - preeclampsia and none-preeclampsia diagnosed pregnant women. Exclusion Criteria: - Known or reported kidney disease.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• No intervention
No intervention

Locations
Country Name City State
Israel Barzilai Medical Center Ashkelon

Sponsors (1)
Lead Sponsor Collaborator
Barzilai Medical Center

Country where clinical trial is conducted

Israel, 

Outcome
Type Measure Description Time frame Safety issue
Primary Uric Acid mg/dL through study completion, an average of 1 year
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