Clinical Effectiveness of First Trimester Pre-eclampsia Screening Program.

Status Recruiting

Clinical Trial Summary

To evaluate the clinical effectiveness of this screening program in preventing pre-eclampsia.

Clinical Trial Description

The incidence of pre-eclampsia is about 2-8%, it is a leading cause of maternal and perinatal mortality and morbidity. Both ACOG (American Congress of Obstetricians and Gynecologists) and NICE (National Institute for Health and Clinical Excellence) guideline advocate the use of traditional screening method, which uses demographic characters and medical history to identify high risk women. This method detects only 35-40% of pre-eclampsia women. Study has shown that combination of maternal factors and biomarkers (uterine artery pulsatility index, placenta growth factor, PlGF; pregnancy associated plasma protein-A, PAPP-A) improves the detection rate. In Taiwan, the prevalence of pre-eclampsia is about 1.21%. The incidence of pre-eclampsia is correlated with maternal age, with a relative risk of 5.13-fold in women aged 40 and above. Marrying late predisposes these women at high risk of developing pre-eclampsia. Our institution will be implementing first-trimester screening program starting from April 2019, this study aims to evaluate the clinical effectiveness of this screening program in preventing pre-eclampsia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04021680
Study type	Observational
Source	Far Eastern Memorial Hospital
Contact	Sheng-Mou Hsiao, MD
Phone	+88689667000
Email	smhsiao2@gmail.com
Status	Recruiting
Phase
Start date	June 10, 2019
Completion date	June 20, 2025

View Details

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