Pre-Eclampsia Clinical Trial
Official title:
Interest of Circulating Endothelial Biomarkers in Vascular Pregnancy Complications
This is a prospective multicentric study including four clinical units of Gynecology and
Obstetrics (3 public health hospitals and one private team), one research team in Hematology
and one Center of Clinical investigation (CIC).
The objective is to identify, beside the pregnancy, in a population of patients with a
preeclampsia (PE), with fetus presenting with growth restriction (IUGR) and a fetal demise
(FD) a modification of circulating endothelial biomarkers compared with normal pregnancy.
We want to understand better the physiopathology of preeclampsia and propose to patients
with an endothelial dysfunction a early prevention of preeclampsia.
Patients will be tested 3 times : At the pregnancy events; then 8 weeks and 12 months after
the birth.
Four groups will be constituted among patients: PE, IUGR, FD and normal pregnancy.
Normal pregnancy will be tested as controls. The next pregnancy presenting in the unit to
medical pregnancy follow up will be invited to participate.
The main judgment criteria will be the levels of endothelial microparticles 8 weeks after
the event.
The study will last 3 years. The number of patient to include is 280.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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