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NCT00262093 Clinical Trial

Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence

Pre-Eclampsia Clinical Trial

Official title:
Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00262093
Other study ID # PRIMIMULTI-HMO-CTIL
Secondary ID
Status Recruiting
Phase N/A
First received December 4, 2005
Last updated March 19, 2007
Start date November 2005

Study information
Verified date November 2005
Source Hadassah Medical Organization
Contact Yuval Bdolah, MD, MSc
Phone 972-2-5844111
Email ybdolah@hadassah.org.il
Is FDA regulated No
Health authority Israel: Israeli Health Ministry Pharmaceutical Administration
Study type Observational

Clinical Trial Summary

The reason for having a higher incidence of preeclampsia in primiparas may involve angiogenesis imbalance in these patients.

Description:

Primiparity is one of the main risk factors for having preeclampsia during pregnancy. Recently, sFlt-1, soluble FMS-like tyrosine kinase-1, has been shown to be a major molecule involved in the pathogenesis of preeclampsia. Higher sFlt-1 mRNA, higher serum levels of sFlt-1 as well as lower PlGF, placental growth factor, have been found in preeclamptic patients.

We intend to check the angiogenesis profile of primiparas as compared to multiparas.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group N/A and older
Eligibility Inclusion Criteria:

- Every delivery

Exclusion Criteria:

- Preeclampsia or pregnancy induced hypertension

Study Design

Observational Model: Case Control, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Hadassah Medical Organization Jerusalem

Sponsors (2)
Lead Sponsor Collaborator
Hadassah Medical Organization Beth Israel Deaconess Medical Center

Country where clinical trial is conducted

Israel, 

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